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This trial demonstrated that once-weekly administration of the highest dose of a unimolecular triple-agonist (GLP1RA–GIPRA–GCGRA) by subcutaneous injection in people with obesity and T2DM induces weight loss that appears comparable to that achieved with bariatric surgery, with a favourable safety and tolerability profile

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10.1016/j.neubiorev.2018.08.018 46 DeslandesP